Thursday, 13th February
32nd Lorne Cancer 2020
Days
Thursday, 13th February
Friday, 14th February
Saturday, 15th February
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Speakers
Welcome
2:00PM - 2:10PM
Thursday, 13th February
Auditorium
Session 1: Hematology
2:10PM - 3:40PM
Thursday, 13th February
Auditorium
Chairs: Richard Lock & Mark Dawson
Malignant Deamination Drives Pre-cancer Stem Cell evolution
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Catriona Jamieson
Unexpected tumour heterogeneity in CLL relapse on venetoclax revealed by single cell analysis
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Rachel Thijssen
Identification of novel tumour suppressor genes in vivo using CRISPR/Cas9
-
Shinsuke Mizutani
RNA splicing alterations induce a cellular stress response associated with poor prognosis in AML
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Ashwin Unnikrishnan
Predicting resistance factors to MCL-1 targeting BH3-mimetic drugs using accurate pre-clinical models of lymphoma
-
Gemma Kelly
Afternoon Tea
3:40PM - 4:30PM
Thursday, 13th February
Trade Area Level 2&3
Session 2: Function Genomics & Flash Talks
4:30PM - 6:20PM
Thursday, 13th February
Auditorium
Chairs: Mark Shackleton & Andrew Roberts
The Discovery of Paralogous Gene Dependencies in Cancer
-
William Sellers
NOVEL EGFRvIII CAR T CELLS ARE AN EFFECTIVE TREATMENT FOR GLIOBLASTOMA
-
Rebecca C Abbott
Chromosome arm aneuploidies shape tumour evolution, cancer prognosis and drug response
-
Ankit Shukla
Deep profiling by mass cytometry reveals differing T cell activation in ever- and never-smoker lung cancer
-
Clare Weeden
DNA barcoding demonstrates immuno-editing of metastatic and non-metastatic breast cancer cells at the clonal level
-
Simon Junankar
Identifying co-operative drivers and novel therapeutic targets in SMAD4-deficient oesophageal adenocarcinoma
-
Julia V Milne
Using genomics and pre-clinical models to improve treatment options for patients with rare cancers
-
Holly E Barker
In vivo
imaging of the Akt-FRET biosensor mouse
-
Max Nobis
“Immuno-flowFISH”: Next-generation cytogenetic assessment provides unique insight into Chronic Lymphocytic Leukemia
-
Henry Hui
BRCA1 mutation stabilises cyclin E1 in breast cancer to create a therapeutically targetable subset
-
Elizabeth Caldon
Spliced HLA bound peptides, a new class of antigens for cancer immunotherapy
-
Pouya Faridi
Identification of a novel tumour macrophage progenitor
-
Shweta Tikoo
Cep55
loss impedes tumorigenesis
in vivo
-
Behnam Rashidieh
MITF-mediated changes of tumour architecture, tensile stress and in extracellular matrix (ECM) control intratumour heterogeneity in melanoma
-
Nikolas K Haass
Cell polarity and tumor organoids for cancer biology and personalized medicine
-
Senthil Muthuswamy
Festival of Food
6:20PM - 8:00PM
Thursday, 13th February
Umisango, Jashn & Lorne Central
Poster Session I & Flash Talk Posters
8:00PM - 10:00PM
Thursday, 13th February
Trade Area Level 2&3
FLASH TALK POSTERS
NOVEL EGFRvIII CAR T CELLS ARE AN EFFECTIVE TREATMENT FOR GLIOBLASTOMA
-
Rebecca C Abbott
Chromosome arm aneuploidies shape tumour evolution, cancer prognosis and drug response
-
Ankit Shukla
Deep profiling by mass cytometry reveals differing T cell activation in ever- and never-smoker lung cancer
-
Clare Weeden
DNA barcoding demonstrates immuno-editing of metastatic and non-metastatic breast cancer cells at the clonal level
-
Simon Junankar
Identifying co-operative drivers and novel therapeutic targets in SMAD4-deficient oesophageal adenocarcinoma
-
Julia V Milne
Using genomics and pre-clinical models to improve treatment options for patients with rare cancers
-
Holly E Barker
In vivo
imaging of the Akt-FRET biosensor mouse
-
Max Nobis
“Immuno-flowFISH”: Next-generation cytogenetic assessment provides unique insight into Chronic Lymphocytic Leukemia
-
Henry Hui
BRCA1 mutation stabilises cyclin E1 in breast cancer to create a therapeutically targetable subset
-
Elizabeth Caldon
Spliced HLA bound peptides, a new class of antigens for cancer immunotherapy
-
Pouya Faridi
Identification of a novel tumour macrophage progenitor
-
Shweta Tikoo
MITF-mediated changes of tumour architecture, tensile stress and in extracellular matrix (ECM) control intratumour heterogeneity in melanoma
-
Nikolas K Haass
CDK4/6 Inhibition: a novel chemosensitizing agent in the treatment of Medulloblastoma
-
Christelle Adolphe
Measuring nano-drug delivery: Development of quantitative visualisation of nanoparticle penetration kinetics in 3D tumour spheroids
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Aria Ahmed-Cox
Linking multi-modal single-cell RNA sequencing with targeted long-read sequencing reveals the clonal and transcriptional profile of lymphocytes
-
Ghamdan Al-Eryani
Investigating The role of AIM2 Inflammasome in Lung Adenocarcinoma
-
Mohammad Alanazi
Cannabinoids effectively block proliferation of paediatric medulloblastoma cells in vitro
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Clara Andradas Arias
A cellular atlas of treatment-naïve primary prostate cancer generated using single-cell RNA-seq
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Eva Apostolov
Immune modulation using timed-synchronized SBRT-partial tumor irradiation targeting the hypoxic tumor segment (SBRT-PATHY) for global systemic effects
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Martin L Ashdown
Novel role of NEDD4 E3 ligase in exosomes secretion and chemoresistance
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Ishara Atukorala
Δ40p53 inhibits the p53-mediated response to DNA damaging therapies in breast cancer cells
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Luiza Steffens Reinhardt
Characterising immune evasive sub-clones of 4T1 breast cancer cells to identify new effective breast cancer immunotherapy targets
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Louise Baldwin
Iron overload targeted in glioblastoma using iron-depleted bovine lactoferrin protein
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Tulika Basak
Nucleic acid aptamers as alternative affinity reagents for precision oncology
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Michelle Bauer
Novel Zirconium-89-radiolabelling of therapeutic antibody for the detection of PD-L1 expression by PET imaging
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Benjamin Blyth
Developing a model of high grade serous ovarian carcinoma using CRISPR/Cas9
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Nirashaa T Bound
Characterisation of molecular response to the RNA polymerase I transcription inhibitor CX-5461 in olaparib-resistant ID8 mouse ovarian cancer cells
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Natalie Brajanovski
Predicting and targeting immune cold breast cancer
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Natasha K Brockwell
CHK1/2 inhibition synergises with radiotherapy in preclinical models of medulloblastoma enabling a reduction in radiation dosage without compromising survival
-
Jessica Buck
Exploring Gamma Delta T Cells in Merkel Cell Carcinoma
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Alexander Caneborg
A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming
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Michael Cangkrama
DCLK1: a novel promoter of gastric cancer progression
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Annalisa Carli
A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death
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Sophia Ceder
The role of calcium channel drugs in lipopolysaccharide (LPS) induced oral cancer cell proliferation
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Rajdeep Chakraborty
Inhibition of the NPY signalling axis as a novel therapeutic option in pancreatic cancer
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Cecilia Chambers
Targeting gp130-dependent cytokine signalling in gastrointestinal cancers
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Ashwini Chand
Successful photodynamic treatment of murine ovarian cancers using Photosoft
TM
photosensitising technology
-
Yiqian Chen
AXMAP – the Australian pdX MelanomA Project
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Jen G. Cheung
BMP4 inhibits breast cancer metastasis independent of tumour SMAD4 expression
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Lap Hing Chi
Preclinical assessment of epigenetic therapy using decitabine to treat endocrine-resistant breast cancer
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Kee Ming Chia
Tumor Exosomes: Novel Regulators of Cancer Cachexia
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Sai Vara Prasad Chitti
Histone deacetylase inhibitor as a differentiation therapy for lung adenocarcinoma
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Wai Chin Chong
Identification of RNA splicing therapeutic targets in high-risk paediatric acute leukaemia
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Adria Closa
The clinical utility of circulating tumour DNA in oesophageal cancer
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Mariana Corrales Benitez
Targeting CAF mediated stromal remodeling to disrupt pro-metastatic and chemo-protective tumour microenvironments
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Thomas R. Cox
Examining the impact of FKBP25 knockdown on MDA-MB-468 cell proliferation, invasion and migration.
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Tabitha M Cree
Heterogeneity in single-cell apoptotic signalling promotes chemoresistance in neuroblastoma
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David R Croucher
Circulating antibodies as novel cancer biomarkers
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Jessica Da Gama Duarte
Using patient-derived xenograft models to explore disease - a case report of uterine leiomyosarcoma
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Genevieve Dall
Investigating the impact of nutrient availability on chemotherapy resistance in triple-negative breast cancer
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Jasmine V Davis
Overcoming resistance to PI3K inhibitors in colorectal cancer
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Francesc d'Assis de las Heras Vila
Therapeutic effects of
bazedoxifene
in combination with chemotherapy in colon cancer
-
Rhynelle Dmello
Development of small molecule STING agonists that can evoke host anti-cancer immune defences following local or systemic delivery
-
Judith Doherty
c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis
-
Yuchen Feng
Intestinal Epigenetic Age Determines Risk of Braf Mutant Colorectal Neoplasia
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Lochlan Fennell
Precision medicine for high-risk paediatric and AYA sarcomas
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Emmy Fleuren
Exosomes containing oncogenic mutant β-catenin activate Wnt signaling pathway in the recipient cells
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Pamali Fonseka
THERAPEUTIC RESTORATION OF IMMUNE SIGNALLING PATHWAYS IN METASTASIS
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Miriam Fuentes
APR-246 targets mitochondrial metabolism through depletion of low-molecular weight thiols
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Kenji Fujihara
Automated enumeration of plasma cells in bone marrow trephine biopsies of multiple myeloma
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Kathy Fuller
Multiple interaction nodes define the post-replication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load
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Brian Gabrielli
Targeting Mind Bomb-2 and MIP, new Regulators of Tumour cell Survival in TRAIL Signaling
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Anna Gabrielyan
A functional blood brain barrier is required for the effective translation of novel therapeutic agents for paediatric brain tumours
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Laura A Genovesi
Non-oncogenic addiction to autophagy in breast cancer progression.
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Charlett M Giuliani
Ultra-Rapid and accurate data analysis solution for TSO500 ctDNA: Enabling comprehensive genomic profiling with a plasma-based assay
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Gerald Goh
Loss of ABCB1 predicts for sensitisation to spliceosomal modulation with H3B-8800 – potential implications in the context of monosomy 7 and the myelodysplastic syndromes
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Andrew A Guirguis
Anti-tropomyosin drugs prevent the rescue of vincristine-induced mitotic spindle defects
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Peter Gunning
Uncovering biomechanically regulated cellular processes of melanoma cell invasion and survival in confined environments
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Nikolas K Haass
Bortezomib induces immunogenic cell death in melanoma and enhances immune response in vivo
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Nikolas K Haass
Regorafenib - A TME-modulating RTK inhibitor for the treatment of pancreatic cancer
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Tanja Haegele
Modelling chemotherapy-induced apoptosis to improve response in high-risk neuroblastoma
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Jeremy Han
MRP1 modulators sensitise resistant cancer cells to treatment
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Kimberley M Hanssen
Investigating the Clinical Significance of Fibroblast Growth Factor Inducible 14 in Breast Cancer
-
Joshua Harris
Remodeling of metastatic vasculature reduces lung colonisation and sensitises overt metastases to immunotherapy
-
Bo He
Identification of novel compounds that induce translational readthrough of nonsense mutant TP53
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Angelos Heldin
Inhibition of tumour initiation by a novel small molecule compound through reactivating the death response in MYCN-driven cancer
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Mika Herath
Harnessing the innate immune response to treat small cell lung cancer.
-
Jonas Hess
Agonizing about antagonizing the androgen receptor in estrogen receptor positive breast cancer
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Theresa Hickey
Network informed analysis of Mucinous Ovarian Carcinoma
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Jessica Holien
MicroRNA-based therapeutics for the treatment of high-risk neuroblastoma
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Holly Holliday
Vulnerabilities in glutamine metabolism define triple-negative from Luminal A breast cancer subtypes
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Jeff Holst
Determining the clinical utility of anti-CD47, an immune modulating antibody, as a therapeutic agent in aggressive paediatric brain tumours.
-
Meegan Howlett
Developing personalized chemotherapy/targeted treatment for sarcoma patients via PDX testing and patient/tumour/PDX genomic analysis
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Evan Ingley
Interrogating the cell-of-origin of
BRCA1
mutant ovarian cancer to inform targeted strategies for cancer prevention
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Rachel Joyce
Cep55 overexpression causes tumorigenesis in mice though multiple mechanisms
-
Murugan Kalimutho
Oncogenic β-catenin regulates partial senescence and secretion of exosomes
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Taeyoung Kang
Visualization of endogenous p27 and Ki67 reveals oxidative phosphorylation-dependent survival of quiescent melanoma cells
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Ting La
CHK1 inhibitor + subclinical dose of hydroxyurea selectively kills melanomas and non-small cell lung cancers in an immunogenic manner, activates the STING pathway and triggers an immunomodulatory response in vivo.
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Brian Gabrielli
Enhancing the efficacy of microtubule targeting agents through cytoskeletal crosstalk
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Sharissa L Latham
Macrophage-secreted Oncostatin M dictates metastatic potential via functional reprogramming of inflammatory fibroblast polarity in pancreatic ductal adenocarcinoma
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Brian Y Lee
piRNA pathway genes decrease ovarian cancer invasion and can be regulated by gonadotropins
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Eunice Lee
The role of BH-3 mimetic drugs in overcoming immunotherapy resistance in melanoma
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ZIZHEN MING
Robotic-assisted complete mesocolic excision, central vascular ligation and para-aortic lymph node dissection in multifocal carcinoid: A case report and technical description
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Rebekah Young
Robotic complete mesocolic excision using idocyanine fluorescence imaging in colorectal cancer: A case study and technical approach.
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Rebekah Young
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